HMG 75 IU

Quickstart Highlights

Human Menopausal Gonadotropin (HMG) is a purified gonadotropin preparation containing equal amounts of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity[1][2]. In males, HMG is used alongside hCG to stimulate spermatogenesis in cases of hypogonadotropic hypogonadism or infertility[3][4]. This educational protocol presents a thrice-weekly subcutaneous approach for male fertility support.

Reconstitute: Add 3.0 mL bacteriostatic water → 25 IU/mL concentration.
Typical protocol: 75 IU three times weekly for 12–16 weeks, usually combined with hCG therapy.
Volume consideration: Each 75 IU dose = 3.0 mL, requiring a 3 mL syringe or multiple 1 mL injections.
Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); after reconstitution, use promptly or refrigerate and use within a few days.

Dosing & Reconstitution Guide

Educational guide for reconstitution and daily dosing

Male Fertility Protocol (3 mL = 25 IU/mL)

Week/Phase	Dose per Injection	Volume per Injection
Weeks 1–12	75 IU (0.15 mg)	3.0 mL (300 units)
Weeks 13–16 (optional extension)	75 IU (0.15 mg)	3.0 mL (300 units)

Frequency: Inject three times per week subcutaneously (for example, Monday, Wednesday, and Friday)[3][4]. HMG therapy is typically combined with hCG injections to maximize testosterone production and spermatogenesis[5][6].
Important Volume Note: Each full 75 IU dose requires 3.0 mL, which exceeds standard 1 mL insulin syringe capacity. Options include:
Use a 3 mL syringe (preferred for single injection)
Split dose into three 1 mL injections at different sites (1 mL = 25 IU each)
Consider smaller reconstitution volume (1 mL) per manufacturer guidance for reduced injection volume[8] Open source

Reconstitution Steps

Reference-derived details for HMG 75 IU.

Draw 3.0 mL bacteriostatic water with a sterile 3 mL syringe.
Inject slowly down the vial wall to avoid foaming.
Gently swirl or roll the vial until fully dissolved (do not shake).
Label with date and time; refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
For optimal potency, use reconstituted solution promptly or within a few days[9]. Open source

Supplies Needed

Plan based on a 12–16 week male fertility protocol with thrice-weekly administration.

Peptide Vials (HMG, 75 IU / 0.15 mg each):
Peptide Vials (HMG, 75 IU / 0.15 mg each):: 12 weeks ≈ 36 vials (3 per week × 12 weeks)
Peptide Vials (HMG, 75 IU / 0.15 mg each):: 16 weeks ≈ 48 vials (3 per week × 16 weeks)
Syringes (3 mL):Note: If using 1 mL insulin syringes, multiply counts by 3 for split-dose administration.
Syringes (3 mL):Note: If using 1 mL insulin syringes, multiply counts by 3 for split-dose administration.: Per week: 3 syringes (one per injection)
Syringes (3 mL):Note: If using 1 mL insulin syringes, multiply counts by 3 for split-dose administration.: 12 weeks: 36 syringes
Syringes (3 mL):Note: If using 1 mL insulin syringes, multiply counts by 3 for split-dose administration.: 16 weeks: 48 syringes
Bacteriostatic Water (30 mL bottles): Use 3.0 mL per vial for reconstitution.
Bacteriostatic Water (30 mL bottles): Use 3.0 mL per vial for reconstitution.: 12 weeks (36 vials): 108 mL → 4 × 30 mL bottles
Bacteriostatic Water (30 mL bottles): Use 3.0 mL per vial for reconstitution.: 16 weeks (48 vials): 144 mL → 5 × 30 mL bottles
Alcohol Swabs: One for the vial stopper + one for each injection site.
Alcohol Swabs: One for the vial stopper + one for each injection site.: Per week: 6 swabs (2 per injection day)
Alcohol Swabs: One for the vial stopper + one for each injection site.: 12 weeks: 72 swabs → recommend 1 × 100-count box
Alcohol Swabs: One for the vial stopper + one for each injection site.: 16 weeks: 96 swabs → recommend 1 × 100-count box

Protocol Overview

Concise summary of the thrice-weekly male fertility regimen.

Goal: Stimulate spermatogenesis in males with hypogonadotropic hypogonadism or infertility[3][4]. Open source
Schedule: Subcutaneous injections three times weekly for minimum 12 weeks (extend to 16 weeks if needed)[7]. Open source
Dose: 75 IU (0.15 mg) per injection, typically combined with hCG therapy[5][6]. Open source
Reconstitution: 3.0 mL per 75 IU vial (25 IU/mL) for calculation convenience.
Storage: Lyophilized refrigerated; reconstituted solution used promptly or within days when refrigerated.

Dosing Protocol

Standard male fertility support approach.

Dose: 75 IU three times per week (e.g., Monday, Wednesday, Friday).
Combination Therapy: Usually administered alongside hCG (2–3 times weekly) to support testosterone and maximize spermatogenesis[5][6]. Open source
Cycle Length: Minimum 12 weeks; may extend to 16 weeks based on response[7]. Open source
Route: Subcutaneous injection into fatty tissue (abdomen, thigh, or upper arm)[8]. Open source
Timing: Maintain consistent injection days; rotate sites with each injection.

Storage Instructions

Proper storage maintains HMG stability and potency.

Lyophilized (unopened): Store at 2–8 °C (35.6–46.4 °F) away from light; stable at controlled room temperature up to 25 °C (77 °F)[9]. Open source
Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); for best potency use promptly (official guidance recommends immediate use with plain diluent)[9]. Open source
With bacteriostatic water, reconstituted solution may be refrigerated and used within a few days.
Protect from light at all times; discard any unused solution if not used within recommended timeframe.

Important Notes

Practical considerations for safe and effective administration.

HMG therapy typically requires concurrent hCG administration for optimal results in males[5][6]. Open source
Use new sterile syringes for each injection; dispose in a sharps container[10]. Open source
Rotate injection sites (abdomen, thighs, upper arms) at least 1 inch apart to prevent lipohypertrophy or irritation[11]. Open source
The 3.0 mL injection volume may require splitting into multiple smaller injections or using larger-capacity syringes.
Monitor semen parameters and hormone levels throughout therapy to assess response.
Clinical response typically requires at least 12 weeks; spermatogenesis may take 3–6 months to fully develop[7]. Open source

How This Works

HMG provides both FSH and LH activity in a 1:1 ratio, derived from purified human menopausal urine[1][2]. In males with hypogonadotropic hypogonadism, FSH stimulation is essential for spermatogenesis (sperm production)[3]. When hCG alone fails to induce adequate sperm production, adding HMG provides the necessary FSH activity to support testicular function and fertility[5][6]. Clinical studies demonstrate that HMG combined with hCG significantly improves sperm parameters including motility, morphology, and concentration, with enhanced pregnancy rates in treated couples[7][12].

Potential Benefits & Side Effects

Observations from clinical fertility literature.

Stimulates spermatogenesis in men with hypogonadotropic hypogonadism or secondary infertility[3][4]. Open source
Improves sperm motility, morphology, and concentration when combined with hCG therapy[7][12]. Open source
Significantly increases pregnancy rates in couples undergoing fertility treatment[7]. Open source
Supports normal testicular function and hormone production[5][6]. Open source
Injection site reactions (redness, swelling, mild pain)[8]. Open source
Headache, fatigue, or mood changes (uncommon).
Gynecomastia (breast tissue development) due to hormonal stimulation.
Overstimulation effects if dosing is excessive (rare in males with proper monitoring).
Allergic reactions (rare); discontinue if hypersensitivity occurs.

Lifestyle Factors

Complementary strategies to support fertility outcomes.

Maintain healthy body weight and balanced nutrition rich in antioxidants (zinc, selenium, vitamin C, vitamin E).
Avoid excessive heat exposure to testes (hot tubs, saunas, tight clothing).
Limit alcohol consumption and avoid tobacco and recreational drugs.
Manage stress through adequate sleep, exercise, and relaxation techniques.
Regular moderate exercise supports hormonal balance (avoid excessive endurance training).
Consider coenzyme Q10, L-carnitine, or other evidence-based supplements after consultation.

Injection Technique

Proper subcutaneous injection technique for HMG administration[8][10][11].

Wash hands thoroughly and gather supplies on a clean surface.
Clean the vial stopper with an alcohol swab and allow to dry.
Draw up the prescribed dose using a sterile syringe (3 mL capacity for full 75 IU dose).
Select an injection site with adequate subcutaneous fat (lower abdomen at least 2 inches from navel, outer thigh, or upper arm).
Clean the injection site with a fresh alcohol swab; let dry completely.
Pinch about an inch of skin to create a fold of subcutaneous tissue.
Insert needle at a 90° angle (or 45° if very little subcutaneous fat) into the tissue[10][11]. Open source
Release the pinch and slowly inject the medication over several seconds.
Withdraw the needle smoothly and apply gentle pressure with sterile gauze (do not rub the site).
Dispose of used syringe immediately in a sharps container[10]. Open source
Rotate injection sites with each administration, maintaining at least 1 inch spacing from previous sites[11]. Open source
For Split-Dose Administration: If using 1 mL insulin syringes, divide the 3 mL total into three separate 1 mL injections at different sites (each containing 25 IU). Complete all three injections during the same administration session.

Recommended Source

We recommend Prime Lab Peptides for high-purity HMG (75 IU / 0.15 mg).

High-purity, third-party-tested products with batch Certificates of Analysis (COAs).
Consistent quality control and ISO-aligned handling procedures.
Reliable cold-chain shipping to maintain peptide integrity.
Comprehensive documentation and customer support.

Important Note

This page is informational and does not authorize use. Peptify clients should complete assessment, disclose medications and health history, and follow the clinician-approved plan only.

Do not start, stop, combine, or change a protocol based only on website content.
Emergency symptoms require urgent medical care, not a website or routine follow-up message.

References