CJC-1295 with DAC 5mg

Contents

Use this guide as a structured review page. The same headings appear for every protocol so clients and the care team can scan the page consistently.

Quickstart Highlights

CJC-1295 DAC is a long-acting synthetic analog of growth hormone-releasing hormone (GHRH). The DAC (Drug Affinity Complex) modification binds reversibly to albumin, extending the peptide’s half-life to approximately 6–8 days[1]. By stimulating pituitary GHRH receptors, CJC-1295 DAC increases GH secretion and circulating IGF-1 in a dose-dependent manner[2]. This educational protocol presents a twice-weekly subcutaneous approach using a practical dilution for clear insulin-syringe measurements.

• Reconstitute: Add 2.0 mL bacteriostatic water → 2.5 mg/mL (2500 mcg/mL) concentration.
• Typical dose range: 300–1000 mcg per injection, twice weekly (gradual titration).
• Easy measuring: At 2.5 mg/mL, 1 unit = 0.01 mL = 25 mcg on a U-100 insulin syringe.
• Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.

Dosing & Reconstitution Guide

Educational guide for reconstitution and daily dosing

• Frequency: Inject twice weekly subcutaneously (e.g., Monday/Thursday or Tuesday/Friday). The extended 6–8-day half-life from the DAC modification supports less frequent dosing compared to non-DAC GHRH analogs[1][2]. Once-weekly dosing is also studied; adjust frequency based on protocol requirements.
• For ≤10-unit (≤0.10 mL) administrations, consider 30- or 50-unit insulin syringes for improved readability.

Reconstitution Steps

Reference-derived details for CJC-1295 with DAC 5mg.

• Draw 2.0 mL bacteriostatic water with a sterile syringe.
• Inject slowly down the vial wall; avoid foaming.
• Gently swirl/roll until dissolved (do not shake).
• Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

Supplies Needed

Plan based on an 8–16 week twice-weekly protocol with gradual titration.

• Peptide Vials (CJC-1295 DAC, 5 mg each):
• Peptide Vials (CJC-1295 DAC, 5 mg each):: 8 weeks ≈ 3 vials (~10.2 mg total)
• Peptide Vials (CJC-1295 DAC, 5 mg each):: 12 weeks ≈ 4 vials (~18.2 mg total)
• Peptide Vials (CJC-1295 DAC, 5 mg each):: 16 weeks ≈ 6 vials (~26.2 mg total)
• Insulin Syringes (U-100):
• Insulin Syringes (U-100):: Per week: 2 syringes (twice weekly)
• Insulin Syringes (U-100):: 8 weeks: 16 syringes
• Insulin Syringes (U-100):: 12 weeks: 24 syringes
• Insulin Syringes (U-100):: 16 weeks: 32 syringes
• Bacteriostatic Water (10 mL bottles): Use ~2.0 mL per vial for reconstitution.
• Bacteriostatic Water (10 mL bottles): Use ~2.0 mL per vial for reconstitution.: 8 weeks (3 vials): 6 mL → 1 × 10 mL bottle
• Bacteriostatic Water (10 mL bottles): Use ~2.0 mL per vial for reconstitution.: 12 weeks (4 vials): 8 mL → 1 × 10 mL bottle
• Bacteriostatic Water (10 mL bottles): Use ~2.0 mL per vial for reconstitution.: 16 weeks (6 vials): 12 mL → 2 × 10 mL bottles
• Alcohol Swabs: One for the vial stopper + one for the injection site each injection.
• Alcohol Swabs: One for the vial stopper + one for the injection site each injection.: Per week: 4 swabs (2 per injection × 2 injections)
• Alcohol Swabs: One for the vial stopper + one for the injection site each injection.: 8 weeks: 32 swabs → recommend 1 × 100-count box
• Alcohol Swabs: One for the vial stopper + one for the injection site each injection.: 12 weeks: 48 swabs → recommend 1 × 100-count box
• Alcohol Swabs: One for the vial stopper + one for the injection site each injection.: 16 weeks: 64 swabs → recommend 1 × 100-count box

Protocol Overview

Concise summary of the twice-weekly regimen.

• Goal: Support sustained GH and IGF-1 elevation for research into GH-axis effects[1]. Open source
• Schedule: Twice-weekly subcutaneous injections for 8–12 weeks (extend to 16 weeks if desired).
• Dose Range: 300–1000 mcg per injection with gradual titration.
• Reconstitution: 2.0 mL per 5 mg vial (2.5 mg/mL) for accurate unit measurements.
• Reconstitution: 2.0 mL per 5 mg vial (2.5 mg/mL) for accurate unit measurements.: Storage: Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.

Dosing Protocol

Suggested twice-weekly titration approach.

• Start: 300 mcg per injection twice weekly; increase by ~250 mcg every 2 weeks as tolerated.
• Target: 750–1000 mcg per injection by Weeks 5–12.
• Frequency: Twice per week (subcutaneous), spaced 3–4 days apart.
• Cycle Length: 8–12 weeks; optional extension to 16 weeks.
• Timing: Consistent timing (e.g., evenings); rotate injection sites.

Storage Instructions

Proper storage preserves peptide quality.

• Lyophilized: Store at −20 °C (−4 °F) in dry, dark conditions; minimize moisture exposure.
• Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); stable for 2–4 weeks; avoid freeze–thaw.
• Allow vials to reach room temperature before opening to reduce condensation uptake.

Important Notes

Practical considerations for consistency and safety.

• Use new sterile insulin syringes; dispose in a sharps container.
• Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation.
• Inject slowly; wait a few seconds before withdrawing the needle.
• Document each dose, injection site, and timing to maintain consistency.
• The DAC modification provides sustained release; maintain consistent twice-weekly scheduling.
• The 5 mg vial provides more doses per vial, reducing reconstitution frequency.

How This Works

CJC-1295 DAC mimics endogenous GHRH, binding to GHRH receptors on pituitary somatotrophs to drive GH release[2]. The DAC modification (albumin-binding moiety) keeps the GHRH analog circulating for days rather than minutes, extending the half-life to approximately 6–8 days[1]. The resulting GH surge stimulates IGF-1 production (primarily in the liver); IGF-1 then mediates many growth and metabolic effects through JAK/STAT signaling pathways[4]. Notably, pulsatile GH secretion persists even during continuous CJC-1295 stimulation, preserving physiological release patterns[2].

Potential Benefits & Side Effects

Observations from preclinical and clinical literature.

• Supports sustained elevation of GH and IGF-1 in a dose-dependent manner[1]. Open source
• May promote increased lean body mass, reduced fat mass, and improved body composition consistent with GH/IGF-1 axis activation[4][9]. Open source
• Enhanced protein synthesis and recovery potential through anabolic signaling[4]. Open source
• Generally well tolerated in clinical studies; occasional mild injection-site reactions (redness, swelling) may occur[1]. Open source
• Some individuals report transient flushing, headache, or water retention during initial titration.

Lifestyle Factors

Complementary strategies for best outcomes.

• Pair with a balanced, protein-forward diet tailored to energy and recovery needs.
• Combine resistance training and aerobic activity to reinforce GH-mediated adaptations.
• Prioritize quality sleep (7–9 hours) as endogenous GH release peaks during deep sleep[4]. Open source
• Manage stress to support hormonal balance and adherence.

Injection Technique

General subcutaneous guidance from clinical best-practice resources[5][6].

• Clean the vial stopper and skin with alcohol; allow to dry.
• Pinch a skinfold; insert the needle at 45–90° into subcutaneous tissue[5][8]. Open source
• Do not aspirate for subcutaneous injections; inject slowly and steadily[5]. Open source
• Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy[6][7]. Open source
• Do not rub or massage the injection site after administration[8]. Open source

Recommended Source

We recommend Pure Lab Peptides for high-purity CJC-1295 DAC (5 mg).

• High-purity, third-party-tested lots with batch COAs.
• Consistent, ISO-aligned handling and documentation.
• Reliable fulfillment to maintain cold-chain integrity.
• Shop at Pure Lab Peptides

Important Note

This page is informational and does not authorize use. Peptify clients should complete assessment, disclose medications and health history, and follow the clinician-approved plan only.

• Do not start, stop, combine, or change a protocol based only on website content.
• Emergency symptoms require urgent medical care, not a website or routine follow-up message.

References

— Teichman SL et al. Prolonged stimulation of GH and IGF-1 by CJC-1295 in healthy adults

• CJC-1295 DAC (5mg Vial) Open source
• — Ionescu M et al. Pulsatile GH secretion persists during continuous CJC-1295 stimulation